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Postnatal maturation of the DG progresses faster in the rat compared with the mouse. (A) Immunohistochemical depiction of DCX- (magenta) and CB-expressing GCs (green) in the mouse and rat DG at P14 and (B) at P21. (C) The comparison of DCX-positive GC distribution between mice and rats from P7 to P42 reveals that the proportion of DCX-expressing cells decreased more rapidly in the rat. Significant differences in the number of DCX-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05) and P21. There were no significant differences in the proportion of DCX-positive cells between P35 and P42 within groups, indicating that a steady state of DCX expression has been reached in both, mice and rats. A <t>monoexponential</t> fit was used to determine the average age at which 50% of Prox1-positive cells were DCX-positive (i.e., t 50%Prox1 ) in each species (black dashed lines). While for mice, t 50%Prox1 was at 14 days, in the rat, it was at 10 days. Furthermore, the time to half maximum decay of DCX expression from the first data point at P7 was determined for each species (i.e., t 50%DCX ). In mice t 50%DCX was at 18 days, whereas in rats, t 50%DCX occurred at 12 days (orange dashed lines). (D) The proportion of CB-positive GCs increased more quickly in the rat compared with GCs in the mouse. Significant differences in the number of CB-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05), P21 and P35. In the mouse t 50%Prox1 for Prox1-positive GCs expressing CB was 19 days, while in the rat, t 50%Prox1 occurred at 14 days (black dashed lines). These findings suggest that GCs mature faster in the rat compared with the mouse. Mouse: n P7 = 4; n P14 = 3; n P21 = 3; n P28 = 5; n P35 = 5; n P42 = 3. Rat: n P7 = 3; n P14 = 3; n P21 = 4; n P28 = 3; n P35 = 3; n P42 = 4. n = number of animals. Error bars represent SEM. * P < 0.05. Scale bars: 10 μm.
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Postnatal maturation of the DG progresses faster in the rat compared with the mouse. (A) Immunohistochemical depiction of DCX- (magenta) and CB-expressing GCs (green) in the mouse and rat DG at P14 and (B) at P21. (C) The comparison of DCX-positive GC distribution between mice and rats from P7 to P42 reveals that the proportion of DCX-expressing cells decreased more rapidly in the rat. Significant differences in the number of DCX-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05) and P21. There were no significant differences in the proportion of DCX-positive cells between P35 and P42 within groups, indicating that a steady state of DCX expression has been reached in both, mice and rats. A monoexponential fit was used to determine the average age at which 50% of Prox1-positive cells were DCX-positive (i.e., t 50%Prox1 ) in each species (black dashed lines). While for mice, t 50%Prox1 was at 14 days, in the rat, it was at 10 days. Furthermore, the time to half maximum decay of DCX expression from the first data point at P7 was determined for each species (i.e., t 50%DCX ). In mice t 50%DCX was at 18 days, whereas in rats, t 50%DCX occurred at 12 days (orange dashed lines). (D) The proportion of CB-positive GCs increased more quickly in the rat compared with GCs in the mouse. Significant differences in the number of CB-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05), P21 and P35. In the mouse t 50%Prox1 for Prox1-positive GCs expressing CB was 19 days, while in the rat, t 50%Prox1 occurred at 14 days (black dashed lines). These findings suggest that GCs mature faster in the rat compared with the mouse. Mouse: n P7 = 4; n P14 = 3; n P21 = 3; n P28 = 5; n P35 = 5; n P42 = 3. Rat: n P7 = 3; n P14 = 3; n P21 = 4; n P28 = 3; n P35 = 3; n P42 = 4. n = number of animals. Error bars represent SEM. * P < 0.05. Scale bars: 10 μm.

Journal: Frontiers in Neuroanatomy

Article Title: Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats

doi: 10.3389/fnana.2017.00104

Figure Lengend Snippet: Postnatal maturation of the DG progresses faster in the rat compared with the mouse. (A) Immunohistochemical depiction of DCX- (magenta) and CB-expressing GCs (green) in the mouse and rat DG at P14 and (B) at P21. (C) The comparison of DCX-positive GC distribution between mice and rats from P7 to P42 reveals that the proportion of DCX-expressing cells decreased more rapidly in the rat. Significant differences in the number of DCX-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05) and P21. There were no significant differences in the proportion of DCX-positive cells between P35 and P42 within groups, indicating that a steady state of DCX expression has been reached in both, mice and rats. A monoexponential fit was used to determine the average age at which 50% of Prox1-positive cells were DCX-positive (i.e., t 50%Prox1 ) in each species (black dashed lines). While for mice, t 50%Prox1 was at 14 days, in the rat, it was at 10 days. Furthermore, the time to half maximum decay of DCX expression from the first data point at P7 was determined for each species (i.e., t 50%DCX ). In mice t 50%DCX was at 18 days, whereas in rats, t 50%DCX occurred at 12 days (orange dashed lines). (D) The proportion of CB-positive GCs increased more quickly in the rat compared with GCs in the mouse. Significant differences in the number of CB-positive cells between species were found on P14 (two-way ANOVA with Bonferroni correction P < 0.05), P21 and P35. In the mouse t 50%Prox1 for Prox1-positive GCs expressing CB was 19 days, while in the rat, t 50%Prox1 occurred at 14 days (black dashed lines). These findings suggest that GCs mature faster in the rat compared with the mouse. Mouse: n P7 = 4; n P14 = 3; n P21 = 3; n P28 = 5; n P35 = 5; n P42 = 3. Rat: n P7 = 3; n P14 = 3; n P21 = 4; n P28 = 3; n P35 = 3; n P42 = 4. n = number of animals. Error bars represent SEM. * P < 0.05. Scale bars: 10 μm.

Article Snippet: A monoexponential function fit was used to determine the average age at which 50% of Prox1-positive cells were DCX-positive as well as the age when 50% of Prox1-positive cells were CB-positive (i.e., t 50%Prox1 ) for both, mice and rats using the following model: Y = (Y0 − Plateau) * exp (−K * X) + Plateau in GraphPad Prism 6.

Techniques: Immunohistochemical staining, Expressing, Comparison